Hartmut Jaeschke Selected Research

Mitochondrial Proteins (Mitochondrial Protein)

3/2016	Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
12/2015	Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
3/2011	The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

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Hartmut Jaeschke Research Topics

Disease

83	Necrosis 03/2024 - 02/2002
71	Acute Liver Failure (Fulminant Hepatic Failure) 04/2024 - 01/2010
51	Mitochondrial Diseases (Mitochondrial Disease) 01/2024 - 02/2002
36	Inflammation (Inflammations) 08/2022 - 10/2003
22	Cholestasis 01/2020 - 04/2004
18	Chemical and Drug Induced Liver Injury 01/2024 - 11/2003
16	Liver Failure 12/2022 - 06/2002
12	Reperfusion Injury 01/2022 - 07/2002
11	Ischemia 01/2022 - 07/2002
10	Liver Diseases (Liver Disease) 01/2021 - 04/2004
6	Poisoning 01/2022 - 01/2015
6	Hemorrhage 01/2017 - 07/2002
6	Fibrosis (Cirrhosis) 06/2010 - 02/2006
5	Non-alcoholic Fatty Liver Disease 01/2022 - 02/2002
5	Hepatitis 01/2019 - 02/2002
5	Infarction (Infarctions) 01/2018 - 02/2006
4	Neoplasms (Cancer) 11/2023 - 11/2014
4	Hepatocellular Carcinoma (Hepatoma) 09/2015 - 09/2005
3	Acute Kidney Injury (Acute Renal Failure) 01/2024 - 12/2020
3	Pain (Aches) 12/2022 - 05/2019
3	Drug-Related Side Effects and Adverse Reactions 12/2019 - 02/2012
3	Sclerosing Cholangitis 06/2010 - 02/2006
3	Endotoxemia 05/2005 - 01/2004
2	Schizophrenia (Dementia Praecox) 01/2021 - 03/2019
2	Obesity 02/2016 - 09/2012
2	Body Weight (Weight, Body) 01/2016 - 05/2015
2	Infections 05/2015 - 12/2009

Drug/Important Bio-Agent (IBA)

148	Acetaminophen (Paracetamol)FDA LinkGeneric 04/2024 - 06/2002
35	Proteins (Proteins, Gene)FDA Link 03/2024 - 10/2005
33	Oxidants (Oxidizing Agents)IBA 03/2024 - 07/2002
20	Biomarkers (Surrogate Marker)IBA 11/2023 - 10/2005
19	Alanine Transaminase (SGPT)IBA 04/2024 - 10/2002
17	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 02/2006
14	Peroxynitrous Acid (Peroxynitrite)IBA 01/2024 - 11/2002
13	Glutathione (Reduced Glutathione)IBA 03/2021 - 06/2002
9	antiarrhythmic peptide (AAP)IBA 11/2023 - 06/2002
9	Adenosine Triphosphate (ATP)IBA 05/2018 - 02/2002
8	Acetylcysteine (Siran)FDA LinkGeneric 12/2023 - 11/2006
7	AntidotesIBA 12/2023 - 12/2015
7	Oxygen (Dioxygen)IBA 01/2017 - 07/2002
6	CytokinesIBA 08/2022 - 10/2003
6	JNK Mitogen-Activated Protein KinasesIBA 03/2021 - 01/2013
6	CaspasesIBA 08/2020 - 12/2011
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015 - 05/2003
5	Keratin-18 (Keratin 18)IBA 03/2018 - 01/2012
5	XenobioticsIBA 03/2018 - 08/2007
5	fas Receptor (CD95 Antigen)IBA 08/2013 - 06/2002
5	DNA (Deoxyribonucleic Acid)IBA 01/2012 - 10/2003
4	Fomepizole (Antizol)FDA LinkGeneric 11/2023 - 01/2019
4	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 11/2023 - 09/2012
4	ChemokinesIBA 11/2023 - 10/2003
4	IronIBA 06/2023 - 11/2008
4	Phosphotransferases (Kinase)IBA 01/2022 - 03/2009
4	Superoxides (Superoxide)IBA 01/2022 - 07/2002
4	Transaminases (Aminotransferases)IBA 05/2017 - 08/2003
4	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 01/2017 - 01/2004
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2016 - 10/2006
4	GalactosamineIBA 10/2016 - 07/2003
4	EnzymesIBA 02/2016 - 02/2006
4	3-nitrotyrosineIBA 02/2011 - 01/2004
4	Glutathione Disulfide (GSSG)FDA LinkGeneric 07/2010 - 07/2002
3	LigandsIBA 11/2023 - 09/2009
3	InflammasomesIBA 08/2022 - 05/2011
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2022 - 10/2010
3	Protein Kinases (Protein Kinase)IBA 01/2022 - 12/2013
3	N-acetyl-4-benzoquinoneimine (NAPQI)IBA 03/2021 - 01/2010
3	Caspase InhibitorsIBA 08/2020 - 05/2017
3	EndonucleasesIBA 12/2019 - 07/2015
3	AntioxidantsIBA 01/2019 - 07/2002
3	Mitochondrial DNA (mtDNA)IBA 10/2017 - 02/2002
3	Mitochondrial Proteins (Mitochondrial Protein)IBA 03/2016 - 03/2011
3	HMGB1 Protein (HMG1)IBA 03/2015 - 01/2012
3	MicroRNAs (MicroRNA)IBA 11/2014 - 07/2014
3	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 11/2014 - 10/2003
3	Heme Oxygenase-1IBA 07/2013 - 01/2004
3	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 06/2010 - 08/2007
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 03/2024 - 02/2016
2	CXC ChemokinesIBA 11/2023 - 05/2005
2	4-aminophenolIBA 12/2022 - 06/2021
2	Ethylene Glycol (Monoethylene Glycol)IBA 01/2022 - 01/2019
2	Methanol (Carbinol)IBA 01/2022 - 01/2019
2	Analgesics (Analgesic Drugs)IBA 12/2021 - 08/2020
2	Cysteine (L-Cysteine)FDA Link 01/2021 - 06/2013
2	quinone (benzoquinone)IBA 12/2020 - 03/2016
2	IminesIBA 12/2020 - 03/2016
2	Mitochondrial Permeability Transition PoreIBA 12/2019 - 07/2010
2	Toll-Like Receptors (Toll-Like Receptor)IBA 10/2018 - 01/2012
2	ConnexinsIBA 08/2017 - 01/2016
2	Eosine Yellowish-(YS) (Eosin)IBA 05/2017 - 11/2014
2	Hematoxylin (Haematoxylon)IBA 05/2017 - 11/2014
2	Apoptosis Inducing FactorIBA 02/2017 - 12/2013
2	endonuclease GIBA 02/2017 - 11/2006
2	LipopolysaccharidesIBA 10/2016 - 01/2011
2	Furosemide (Lasix)FDA LinkGeneric 02/2016 - 02/2014
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2015 - 06/2015
2	deoxyuridine triphosphateIBA 11/2014 - 10/2003

Therapy/Procedure

8	Ligation 01/2020 - 10/2004
7	Liver Transplantation 11/2023 - 01/2003
6	Therapeutics 11/2023 - 02/2006
2	Transplantation 01/2022 - 07/2002